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Author Topic: Aminorex Mystery Solved?  (Read 3164 times)
njhorseman
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« on: March 17, 2007, 08:36:37 PM »

Press release from Freedom Health LLC.

PLEASE NOTE THAT I HAVE PUT A QUESTION MARK IN THE SUBJECT LINE, AS THIS STUDY WAS COMMISSIONED BY A COMPANY THAT MANUFACTURES A SUPPLEMENT WHICH, ACCORDING TO SOME SOURCES, HAS BEEN LINKED TO THE POSITIVES.

THE STUDY MAY BE 100% CORRECT, BUT TO REALLY BE ACCEPTED AS THE ANSWER TO THE AMINOREX MYSTERY, IT NEEDS TO BE INDEPENDENTLY DUPLICATED.



--------------------------------------------------------------------------------
Aminorex Racehorse Mystery Clarified

FOR IMMEDIATE RELEASE

Media Contact:

Scott Carter, PhD

330-562-0888 ext. 107

scarter@freedomhealthllc.com

Aurora, OH (March 17, 2007) - Over the past 2 + years, racehorses
(principally Standardbreds) have tested positive for the amphetamine,
Aminorex. This drug is a Class 1 substance, where positives result in
a 1-5 year suspension from racing. Progressively, rumors have
circulated that certain products may incorporate an ingredient that is
not on the label, including Freedom Health's product: SUCCEED®
Digestive Conditioning Program® ["SUCCEED"]

Freedom Health employed a federally accredited analytical toxicology
laboratory to conduct independent, random sampling of SUCCEED and
analyze these samples using LC/MS/MS analytical procedures for the
presence of Aminorex. These LC/MS/MS procedures are the standard
procedures used by the federal government and racing commissions for
the detection of Aminorex in biological samples.

The LC/MS/MS analysis of random samples of SUCCEED, both oral paste
and granular forms, were NEGATIVE for the presence of Aminorex.

In an effort to further elucidate the reasons behind the rash of
Aminorex positives in the horse racing community, Freedom Health has
learned the following:

1. Using the same LC/MS/MS standard procedures for the detection of
Aminorex, when a commonly used over the counter anthelmetic,
injectable levamisole phosphate, is assayed directly from the original
container, the laboratory reported that it contains a substance that
has a similar molecular weight to Aminorex. However, it has a
different extraction time, which indicates that it is NOT Aminorex.
Other commercially available products, including the non-injectable
forms of levamisole, were NOT found to contain this same compound
using the same analytical LC/MS/MS procedures.
2. When horses were administered a variety of commercially available
wormers and urinalysis was conducted by the laboratory using LC/MS/MS
procedures for the detection of Aminorex, it reported that the
aforesaid compound was only detected in the urine of horses
administered injectable levamisole phosphate. Additionally, laboratory
results showed two other compounds were detected only in the urine of
horses administered injectable levamisole phosphate. These two
additional compounds have the same molecular weight as Aminorex, but
only one of these compounds had an identical extraction time to
Aminorex, indicating a potential positive result for detection of
Aminorex.
3. Using GC/MS analytical techniques to further elucidate the exact
chemical structure of this potential Aminorex compound, laboratory
analysis found that this compound was Aminorex.
4. Laboratory results indicate that the levels of Aminorex in urine
from horses administered injectable levamisole phosphate parallel
those reported in past and current positive results as handed down by
racing authorities.

To summarize, the laboratory results indicate that in our study ONLY
the horses receiving the injectable levamisole phosphate product,
either orally or intramuscularly, resulted in an Aminorex positive
result. Aminorex was NOT found in the product itself, only in the
urine of treated horses after administration of this product, and
never in the urine of horses receiving other anthelmetic products.

John Hall, President and CEO of Freedom Health LLC said "It was vital
that we not only exonerate SUCCEED, but also that we determine the
true cause of these positives to dispel any residual innuendoes. Dr.
Franklin L. Pellegrini, Vice-President of Veterinary Affairs, has
combined his investigatory analyses of the past two years with the
independent analysis of one of the most highly regarded analytical
toxicology teams in the country to finally resolve this conundrum:
Petra G. Hartmann, Director, Drug Testing Services, and her colleagues
at The Industrial Laboratories Company Inc. On February 1, 2007, we
invited Ohio State Racing Commission to monitor this independent
analysis before we commenced. After due consideration at the highest
levels, they declined on February 5."

Dr. Frank Pellegrini said "Friends, colleagues and erstwhile clients
have sought my help when caught in the Aminorex test "trap". It has
made absolutely no sense that reputable trainers would deliberately
use a Class 1 substance, where the recommended penalty effectively
results in a loss of livelihood; much less continue to do so when a
valid test exists for this drug. For two years, I have attempted to
identify a common thread. My investigations became more urgent as
progressive rumors circulated that SUCCEED could be the culprit.
Finally, in January, I believed I had identified this common factor.
It then became imperative that any testing be independent, by the most
capable team in the United States. I therefore approached Petra
Hartmann with my concerns, and asked that she test SUCCEED, and my
suspect materials. I chose The Industrial Laboratories Inc., because
Ms. Hartmann is the vice-chair of the Association of Racing
Commissioners International Testing Integrity Program. We received the
final report today. I am delighted that we can be a part of resolving
this matter for the overall benefit of horse racing in both the USA
and Canada."
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the DailyDaley
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« Reply #1 on: March 18, 2007, 11:02:25 AM »

Imagine that, the "STORE" bought version doesn't test. But why would one think differently?.

A good test report, but possibly self serving. If this was the BIG NEWS Dr. P, then the ORC is way ahead of you.

And PS various parties have discussed the "OTHER POSSIBILITIES" concerning other non-labeled, non-prescribed altered "street" products.

As Ken Chadwick so aptly put a few months ago, can "white people" slip on black ice geezer.

That will be the million dollar dollar question. Very disappointed Dr P. No extremely disappointed in "THE NEWS".

This is like saying the Boston Strangler didn't use a gun.

clocker clocker clocker MARCHES on.

Who is playing their own music. Dr Hook and the MEDICINE SHOW dude.
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Fillmore Bear
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« Reply #2 on: March 18, 2007, 01:43:34 PM »

Standardbred Canada(the Canadian equivalent of USTA) has now posted this on the news page of their website.
Apparently being taken seriously.
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AlongTheRail
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« Reply #3 on: March 18, 2007, 06:24:19 PM »

The sheep wormer that these trainers had given was Tramisol, also known as Levamisole.  And based upon this report, the Levamisole Phosphate is causing the Aminorex positives.  There is no Aminorex in the wormers, but when administered to horses, the urine byproduct is Aminorex.  So that means anyone that owns a horse has there own little meth lab right in front of them.  If this is true, you'll make more money then racing by continually dosing your horse with sheep wormer, collecting the urine, dehydrating it, bagging the powder, and selling it on the street.  Anyone know what the going street value of Aminorex is?  dollar dollar dollar
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the DailyDaley
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« Reply #4 on: March 18, 2007, 07:20:26 PM »

Press release from Freedom Health LLC.

PLEASE NOTE THAT I HAVE PUT A QUESTION MARK IN THE SUBJECT LINE, AS THIS STUDY WAS COMMISSIONED BY A COMPANY THAT MANUFACTURES A SUPPLEMENT WHICH, ACCORDING TO SOME SOURCES, HAS BEEN LINKED TO THE POSITIVES.

THE STUDY MAY BE 100% CORRECT, BUT TO REALLY BE ACCEPTED AS THE ANSWER TO THE AMINOREX MYSTERY, IT NEEDS TO BE INDEPENDENTLY DUPLICATED.



--------------------------------------------------------------------------------
Aminorex Racehorse Mystery Clarified

FOR IMMEDIATE RELEASE

Media Contact:

Scott Carter, PhD

330-562-0888 ext. 107

scarter@freedomhealthllc.com

Aurora, OH (March 17, 2007) - Over the past 2 + years, racehorses
(principally Standardbreds) have tested positive for the amphetamine,
Aminorex. This drug is a Class 1 substance, where positives result in
a 1-5 year suspension from racing. Progressively, rumors have
circulated that certain products may incorporate an ingredient that is
not on the label, including Freedom Health's product: SUCCEED®
Digestive Conditioning Program® ["SUCCEED"]

Freedom Health employed a federally accredited analytical toxicology
laboratory to conduct independent, random sampling of SUCCEED and
analyze these samples using LC/MS/MS analytical procedures for the
presence of Aminorex. These LC/MS/MS procedures are the standard
procedures used by the federal government and racing commissions for
the detection of Aminorex in biological samples.

The LC/MS/MS analysis of random samples of SUCCEED, both oral paste
and granular forms, were NEGATIVE for the presence of Aminorex.

In an effort to further elucidate the reasons behind the rash of
Aminorex positives in the horse racing community, Freedom Health has
learned the following:

1. Using the same LC/MS/MS standard procedures for the detection of
Aminorex, when a commonly used over the counter anthelmetic,
injectable levamisole phosphate, is assayed directly from the original
container, the laboratory reported that it contains a substance that
has a similar molecular weight to Aminorex. However, it has a
different extraction time, which indicates that it is NOT Aminorex.
Other commercially available products, including the non-injectable
forms of levamisole, were NOT found to contain this same compound
using the same analytical LC/MS/MS procedures.
2. When horses were administered a variety of commercially available
wormers and urinalysis was conducted by the laboratory using LC/MS/MS
procedures for the detection of Aminorex, it reported that the
aforesaid compound was only detected in the urine of horses
administered injectable levamisole phosphate. Additionally, laboratory
results showed two other compounds were detected only in the urine of
horses administered injectable levamisole phosphate. These two
additional compounds have the same molecular weight as Aminorex, but
only one of these compounds had an identical extraction time to
Aminorex, indicating a potential positive result for detection of
Aminorex.
3. Using GC/MS analytical techniques to further elucidate the exact
chemical structure of this potential Aminorex compound, laboratory
analysis found that this compound was Aminorex.
4. Laboratory results indicate that the levels of Aminorex in urine
from horses administered injectable levamisole phosphate parallel
those reported in past and current positive results as handed down by
racing authorities.

To summarize, the laboratory results indicate that in our study ONLY
the horses receiving the injectable levamisole phosphate product,
either orally or intramuscularly, resulted in an Aminorex positive
result. Aminorex was NOT found in the product itself, only in the
urine of treated horses after administration of this product, and
never in the urine of horses receiving other anthelmetic products.

John Hall, President and CEO of Freedom Health LLC said "It was vital
that we not only exonerate SUCCEED, but also that we determine the
true cause of these positives to dispel any residual innuendoes. Dr.
Franklin L. Pellegrini, Vice-President of Veterinary Affairs, has
combined his investigatory analyses of the past two years with the
independent analysis of one of the most highly regarded analytical
toxicology teams in the country to finally resolve this conundrum:
Petra G. Hartmann, Director, Drug Testing Services, and her colleagues
at The Industrial Laboratories Company Inc. On February 1, 2007, we
invited Ohio State Racing Commission to monitor this independent
analysis before we commenced. After due consideration at the highest
levels, they declined on February 5."

Dr. Frank Pellegrini said "Friends, colleagues and erstwhile clients
have sought my help when caught in the Aminorex test "trap". It has
made absolutely no sense that reputable trainers would deliberately
use a Class 1 substance, where the recommended penalty effectively
results in a loss of livelihood;
much less continue to do so when a
valid test exists for this drug. For two years, I have attempted to
identify a common thread. My investigations became more urgent as
progressive rumors circulated that SUCCEED could be the culprit.
Finally, in January, I believed I had identified this common factor.
It then became imperative that any testing be independent, by the most
capable team in the United States. I therefore approached Petra
Hartmann with my concerns, and asked that she test SUCCEED, and my
suspect materials. I chose The Industrial Laboratories Inc., because
Ms. Hartmann is the vice-chair of the Association of Racing
Commissioners International Testing Integrity Program. We received the
final report today. I am delighted that we can be a part of resolving
this matter for the overall benefit of horse racing in both the USA
and Canada."

Dr. P so eloquently stated, why would REPUTABLE trainers would use a product as so on.

I guess this implicates the non-reputable trainers geezer.

Your OWN WORDS Dr p.
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bettor2belucky
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« Reply #5 on: March 18, 2007, 08:49:55 PM »

I read it differently as the by product was not Aminorex but a molecular similar weight and the same extraction (breakdown) time as Aminorex. If this is independently verified new testing criteria will be needed to identify this drug, IMO
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"A government big enough to give you everything you want,is a government big enough to take away everything you have."  Thomas Jefferson

"I'm the President I can afford better." Barack Hussein Obama
njhorseman
Guest

« Reply #6 on: March 18, 2007, 08:59:37 PM »

I read it differently as the by product was not Aminorex but a molecular similar weight and the same extraction (breakdown) time as Aminorex. If this is independently verified new testing criteria will be needed to identify this drug, IMO

Your interpretation is incorrect; Please see the following quotes. Both clearly say Aminorex was found in the urine of the treated horses.

"3. Using GC/MS analytical techniques to further elucidate the exact
chemical structure of this potential Aminorex compound, laboratory
analysis found that this compound was Aminorex."

" Aminorex was NOT found in the product itself, only in the
urine of treated horses after administration of this product, and
never in the urine of horses receiving other anthelmetic products."


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Fillmore Bear
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« Reply #7 on: March 18, 2007, 09:43:59 PM »

Dr. P so eloquently stated, why would REPUTABLE trainers would use a product as so on.

I guess this implicates the non-reputable trainers geezer.

Your OWN WORDS Dr p.
Is this a deliberate distortion?Or are you just a moron?
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Fillmore Bear
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« Reply #8 on: March 18, 2007, 09:58:42 PM »

The sheep wormer that these trainers had given was Tramisol, also known as Levamisole.  And based upon this report, the Levamisole Phosphate is causing the Aminorex positives.  There is no Aminorex in the wormers, but when administered to horses, the urine byproduct is Aminorex.  So that means anyone that owns a horse has there own little meth lab right in front of them.  If this is true, you'll make more money then racing by continually dosing your horse with sheep wormer, collecting the urine, dehydrating it, bagging the powder, and selling it on the street.  Anyone know what the going street value of Aminorex is?  dollar dollar dollar
I assume you're joking but will answer the questions:
There is almost no street demand for aminorex.It is easy and cheap to produce for anyone inclined to make home brew drugs.
The amount in the urine of horses is extremely small and probably would be worth way less than the cost of the wormer.Moreover,there is no practical way to purify it from urine.
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njhorseman
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« Reply #9 on: March 19, 2007, 08:55:58 AM »

Is this a deliberate distortion?Or are you just a moron?

That gets the "Rhetorical Question of the Week" award.  Grin
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tonymfan
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« Reply #10 on: March 19, 2007, 10:34:25 AM »

If the levamisole phosphate answer is right why do the positives show up only in certain areas all together? Don't horsemen in other states use the same wormer?
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Fillmore Bear
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« Reply #11 on: March 19, 2007, 11:45:45 AM »

The test for aminorex is new.
As far as anybody knows horsemen have rarely or never used it.
It is not reasonably possible to test every sample for every known chemical.
It does not appear that the the active ingredient in the wormer leads to aminorex,since only one version of the wormer produced it.No manufactured product is absolutely chemically identical from one batch to another.
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Fillmore Bear
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« Reply #12 on: March 19, 2007, 11:49:02 AM »

Another aminorex "positive" reported in Ontario today~~#12.
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talking head
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« Reply #13 on: March 19, 2007, 03:26:27 PM »

If the levamisole phosphate answer is right why do the positives show up only in certain areas all together? Don't horsemen in other states use the same wormer?
Yes sheep wormer is used to stimulate a horses immune system. It has been used in that manner for years. It is also used to coverup some illegal drugs though you need to know how much to use!
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bettor2belucky
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« Reply #14 on: March 19, 2007, 03:29:54 PM »

So would it be correct to say that Aminorex is a byproduct of this particular wormer that is only produced in the urine?...........because if it is, how would they know if it was initially injected or not?   it shows only in the urine as a byproduct but when injected does it show in blood and urine?
« Last Edit: March 19, 2007, 03:33:13 PM by bettor2belucky » Report to moderator   Logged

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"I'm the President I can afford better." Barack Hussein Obama
DLeestable
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« Reply #15 on: March 19, 2007, 03:50:42 PM »

Tramisol has been around for years.  It is the berries for clearing mucus from sick horses.  Any Farm and Fleet carries the stuff. It is not all injectable, they have it in pill form.  It works and its cheap, number one and two reasons horsemen use it.
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Doug Frosch
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« Reply #16 on: March 20, 2007, 07:09:40 AM »

Good Morning Double D,

I am feeling a bit "nefarious" today. Lets wait and see what happens.

Ciao!
« Last Edit: March 20, 2007, 08:16:29 AM by Doug Frosch » Report to moderator   Logged
tonymfan
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« Reply #17 on: March 20, 2007, 10:23:15 AM »

Referencing Waterman statement of nefarious?

http://www.theharnessedge.com/news.asp?Mode=View&Story=19631

NJ horseman is right the study results that started this thread must be duplicated. Something that still doesn't make sense is Ontario says they started testing for the old drug Aminorex because they heard rumors it was being used. Do horsemen start rumors about substances that appear only as inadvertent byproducts in urine?
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Fillmore Bear
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« Reply #18 on: March 20, 2007, 12:17:30 PM »

Stories of tips and rumors(rumours in Canada) are ALWAYS cited as justification for witch hunts.

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the DailyDaley
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« Reply #19 on: March 20, 2007, 12:19:28 PM »

Good Morning Double D,

I am feeling a bit "nefarious" today. Lets wait and see what happens.

Ciao!

It looks like you might be feeling a little "TRUCULENT" also.

tres bien!
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AmyHollar
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« Reply #20 on: March 20, 2007, 12:21:01 PM »

Canada started testing after positives showed up in the states.  Just like I am sure the states are now testing for Toresimide (sp?) after the positives showed up north of the border.

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Do you want cream with that cup of shut the hell up?
AmyHollar
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« Reply #21 on: March 20, 2007, 12:22:53 PM »

HEY NOW!  If I'm going to start needing a dictionary around here I might as well join the illiterate at horsepoopy! maroon










NOT! BSmeter
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Do you want cream with that cup of shut the hell up?
Fillmore Bear
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« Reply #22 on: March 20, 2007, 12:29:32 PM »

Re: Dr. Waterman's statement:

He seems to be quite concerned about the guilty(if there are any)escaping punishment but is completely unconcernerd about punishing the innocent.

If there are both accidental and nefarious aminorex positives,in all probability,the nefarious ones would have a much larger concentration.But the authorities don't want to consider this because it admits the fallacy of what they've been doing for years:doling out ruinous punishments for meaningless traces.    
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tonymfan
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« Reply #23 on: March 20, 2007, 01:17:26 PM »

Re: Dr. Waterman's statement:

He seems to be quite concerned about the guilty(if there are any)escaping punishment but is completely unconcernerd about punishing the innocent.

If there are both accidental and nefarious aminorex positives,in all probability,the nefarious ones would have a much larger concentration.But the authorities don't want to consider this because it admits the fallacy of what they've been doing for years:doling out ruinous punishments for meaningless traces.   

There's no such thing as meaningless trace of a Class I drug. Class I drugs have no business in horses at all. Except "environmental contamination"  Roll Eyes
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Doug Frosch
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« Reply #24 on: March 20, 2007, 02:38:54 PM »

It looks like you might be feeling a little "TRUCULENT" also.

tres bien!

bounteous, is more more like it.

adieu
« Last Edit: March 20, 2007, 02:43:56 PM by Doug Frosch » Report to moderator   Logged
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